Jacob Hildebrand
Jake is a postdoctoral researcher studying the methods that CD8 T cells use to navigate varied microenvironments throughout the host. Specifically, he's interested in what makes certain tissues permissible for T cells, what cues influence their residence or exit into circulation, and how non-immune cells (ie stromal, endothelial cells) shape T cell residence. Outside of lab, he enjoys cooking, exploring the city of Montreal, and is a keen reader of epic fantasy.
Ph.D. in Immunology, University of Minnesota
Supervisor: Dr. Sara Hamilton-Hart
B.S. Biotechnology, University of WI-Stout
Awards
2023-2025: UMN Center for Immunology Training Grant
2023: UMN MICaB Travel Award
2017: UW-Stout CSTEMM Undergraduate Researcher of the Year
2014-2017: UW-Stout Chancellor's Award (7x)
Publications
Hildebrand JA, Lucas ED, Daniels NR, Dehm EM, Fisher BD, Janse CJ, Kim CY, Sangala JA, Tankersley TN, Hart GT, McGavern DB, Hamilton SE. Interleukin-15 complex-induced IL-10 acts on blood endothelial cells to reduce CD8 T cell arrest during cerebral malaria. J Immunol. (In revision, planned resubmission June 2026)
Hildebrand JA, Daniels NR, Dehm EM, Fisher BD, Guter JK, Janse CJ, Lucas ED, Sangala JA, Tankersley TN, Hart GT, Hamilton SE. Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells. PLoS Pathog. 2025 Mar 31; 21(3): e1012993. doi: 10.1371/journal.ppat.1012993
Bravo M, Dileepan T, Dolan M, Hildebrand J, Wolford J, Hanson ID, Hamilton SE, Frosch AE, Burrack KS. IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production. J Immunol. 2024 Mar 15;212(6):992-1001. doi: 10.4049/jimmunol.2300525.
Che M, Chaturvedi A, Munro SA, Pitzen SP, Ling A, Zhang W, Mentzer J, Ku SY, Puca L, Zhu Y, Bergman AM, Severson TM, Forster C, Liu Y, Hildebrand J, Daniel M, Wang TY, Selth LA, Hickey T, Zoubeidi A, Gleave M, Bareja R, Sboner A, Tilley W, Carroll JS, Tan W, Kohli M, Yang R, Hsieh AC, Murugan P, Zwart W, Beltran H, Huang RS, Dehm SM. Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer. Nat Commun. 2021 Nov 4;12(1):6377. doi: 10.1038/s41467-021-26612-1.
Burritt NL, Foss NJ, Neeno-Eckwall EC, Church JO, Hilger AM, Hildebrand JA, Warshauer DM, Perna NT, Burritt JB. Sepsis and Hemocyte Loss in Honey Bees (Apis mellifera) Infected with Serratia marcescens Strain Sicaria. PLoS One. 2016 Dec 21;11(12):e0167752. doi: 10.1371/journal.pone.0167752.